Blar i forfatter "Mahmutovic, Anel"

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    • The Infectious Dose Shapes Vibrio Cholerae Within-Host Dynamics 

      Gillman, Aaron Nicholas; Mahmutovic, Anel; Abel zur Wiesch, Pia; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
      During infection, the rates of pathogen replication, death, and migration affect disease progression, dissemination, transmission, and resistance evolution. Here, we follow the population dynamics of Vibrio cholerae in a mouse model by labeling individual bacteria with one of >500 unique, fitness-neutral genomic tags. Using the changes in tag frequencies and CFU numbers, we inform a mathematical ...

    • RESTAMP – Rate estimates by sequence-tag analysis of microbial populations 

      Mahmutovic, Anel; Gillman, Aaron Nicholas; Lauksund, Silje; Robson Moe, Natasha-Anne; Manzi, Aimé; Storflor, Merete; Abel-Zur Wiesch Genannt Hülsho, Pia Karoline; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
      Microbial division rates determine the speed of mutation accumulation and thus the emergence of antimicrobial resistance. Microbial death rates are affected by antibiotic action and the immune system. Therefore, measuring these rates has advanced our understanding of host-pathogen interactions and antibiotic action. Several methods based on marker-loss or few inheritable neutral markers exist that ...

    • Selection or drift: The population biology underlying transposon insertion sequencing experiments 

      Mahmutovic, Anel; Abel zur Wiesch, Pia; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-25)
      <p>Transposon insertion sequencing methods such as Tn-seq revolutionized microbiology by allowing the identification of genomic loci that are critical for viability in a specific environment on a genome-wide scale. While powerful, transposon insertion sequencing suffers from limited reproducibility when different analysis methods are compared. From the perspective of population biology, this may be ...